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Prognostic implication of proliferative markers MIB-1 and PC10 in esophageal squamous cell carcinoma

✍ Scribed by King-Yin Lam; Simon Ying-Kit Law; Mike Ka-Pui So; Manson Fok; Lily Tung Ma; John Wong

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 667 KB
Volume: 77
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19960101)77:1<7::aid-cncr3>3.0.co;2-n

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Proliferative markers are related to tumor behavior. The commonly used markers are proliferating cell nuclear antigen (PCNA) and Ki-67. The aim of this study is to evaluate the usefulness of MIB-1 (for Ki-67) and PClO (for PCNA) in the assessment of the clinicopathologic features and prognosis in patients with esophageal squamous cell carcinoma.

METHODS.

One hundred patients (88 males, 12 females; mean age, 63 years [range, 39 to 83 years]) with surgically resected esophageal squamous cell carcinoma (32 well differentiated, 51 moderately differentiated, and 17 poorly differentiated) were studied. The clinicopathologic features and survival data of these patients were noted. Representative tissue was collected from each tumor and immunohistochemical preparations for MIB-1 and PCl0 were made.

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