The prognostic value of p53 nuclear overexpression and MIB-1 as a proliferative marker in transitional cell carcinoma of the bladder
β Scribed by Zivko Popov; Andras Hoznek; Marc Colombel; Sylvie Bastuji-Garin; Marie-Aude Lefrere-Belda; Jacqueline Bellot; Claude C. Abbou; Catherine Mazerolles; Dominique K. Chopin
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 447 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0008-543X
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β¦ Synopsis
regions. Patients were stratified for both markers into two groups for time-event 1 Urologic Clinic, Clinical Center, St. Cyril and analysis, according to the median number of nuclei stained. Patients with nuclear Methodius University, Skopje, Macedonia.
staining below the median value of the score were considered negative in the statistical analysis. Quantitative immunostaining was analyzed in relation to the 2 Service d'Urologie et Groupe d'Etude des Tumeurs Urologiques, Centre de Recherches Chirtime to recurrence, progression, and cancer death, and compared with clinical and urgicales, Ho Λpital Henri Mondor, Cre Β΄teil, France.
pathologic parameters for prognostic significance in univariate and multivariate analysis (stepwise logistic regression).
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ful in predicting the clinical outcome of transitional cell carcinoma of the bladder, they also create uncertainty. Immunohistochemical staining for p53, MIB-1, epi-
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