✦ LIBER ✦

Prognostic impact of bcl-2 expression on advanced nasopharyngeal carcinoma

✍ Scribed by Mu-Kuan Chen; Jui-Chung Lai; Cheng-Chuan Chang; Julia H. Chang; Yu-Jun Chang; Hui-Chuan Chen

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 154 KB
Volume: 30
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20839

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Our aim was to evaluate the prognostic impact of bcl‐2 expression on patients with advanced nasopharyngeal carcinoma (NPC).

Methods

One hundred five patients with advanced NPC treated with high‐dose radiotherapy were included. The relationship between bcl‐2 expression, TNM stage, and disease‐specific survival was analyzed.

Results

Within the same stage III and IV, patients with negative bcl‐2 expression had better disease‐free survival. The disease‐free survival of patients with stage IV NPC with negative bcl‐2 expression was paradoxically better than that of patients with stage III NPC with positive bcl‐2 expression. In the advanced NPC, the disease‐free survival of patients with stage III cancer was better than that of patients with stage IV cancer (p = .06); in contrast, patients with bcl‐2‐positive tumors had a worse disease‐free 5‐year survival (p = .02). The Cox regression model revealed that only bcl‐2 expression was statistically significant (p = .03).

Conclusion

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