Expression of bcl-2-, p53, and Ki-67 and outcome of patients with primary nasopharyngeal carcinomas following DNA-damaging treatment
✍ Scribed by Muneyuki Masuda; Atushi Shinokuma; Naoya Hirakawa; Torahiko Nakashima; Sohtaro Komiyama
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 72 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1043-3074
No coin nor oath required. For personal study only.
✦ Synopsis
Background:
Recent studies suggest that apoptosis is important in the cell death induced by treatment that damages deoxyribonucleic acid (dna). we assessed the correlation between the expression of the apoptosis-related proteins, p53 and bcl-2, and the clinical outcome of patients with nasopharyngeal carcinomas (npcs) who were treated with both dna-damaging treatments. we also assessed the level of ki-67, a marker of cell proliferation, in these tumors.
Methods:
We evaluated statistically the relationships among the expression of p53, bcl-2, and ki-67 and clinicopathologic factors, the sensitivity to radiation, the incidence of distant metastases, and survival.
Results:
The group that was positive for p53 tended to be resistant to radiotherapy and to have a significantly poorer prognosis (p = .05).
Conclusions:
The enhanced expression of p53 may be a prognostic factor in patients with npcs whose tumor is resistant to therapy that damages dna.