A study of MCF-7 human breast cancer cells was undertaken to ascertain the degree of apoptosis induction by paclitaxel and if the induction of apoptosis could be enhanced by caffeine. Paclitaxel (0-20 ng/ml) caused concentration-dependent increases in morphologically identifiable apoptotic cells (up
✦ LIBER ✦
Progesterone prevents radiation-induced apoptosis in breast cancer cells
✍ Scribed by Vares, Guillaume; Ory, Katherine; Lectard, Bruno; Levalois, Céline; Altmeyer-Morel, Sandrine; Chevillard, Sylvie; Lebeau, Jérôme
- Book ID
- 110068675
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 410 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
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Resistance to apoptosis plays an important role in tumors that are refractory to chemotherapy and ionizing radiation (IR). bax, which forms a heterddimer with bcl-2 and accelerates apoptosir, is not, or only weakly. expremed in most human breast cancer cells, and weak bax expression is considered to