Progesterone dependence and extratrophoblastic origin of pregnancy-associated plasma protein-A (PAPP-A) in early pregnancy
β Scribed by P. Bischof; A. M. Schindler; R. Wyss; W. L. Herrmann; P. C. Sizonenko
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 430 KB
- Volume
- 237
- Category
- Article
- ISSN
- 0003-9128
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The usefulness of early second-trimester serum determinations of pregnancy-associated plasma protein A (PAPP-A) and pregnancy-specific 1-glycoprotein (SP1) in suspected cases of fetal trisomy 18 was examined in a retrospective, cross-sectional study. Maternal serum PAPP-A and SP1 in 20 cases of feta
## Abstract PregnancyβAssociated Plasma ProteinβA (PAPPβA) proteolyses insulinβlike growth factor binding proteinβ4 (IGFBPβ4), thereby regulating local IGF availability. Reduced PAPPβA mRNA expression has been reported in ovarian cancer specimens compared to normal ovarian surface epithelial cells