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In vitro production of pregnancy-associated plasma protein-A (PAPP-A) by trophoblastic cells

✍ Scribed by E. R. Barnea; M. K. Sanyal; C. Brami; P. Bischof


Publisher
Springer
Year
1986
Tongue
English
Weight
465 KB
Volume
237
Category
Article
ISSN
0003-9128

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## Abstract Pregnancy‐Associated Plasma Protein‐A (PAPP‐A) proteolyses insulin‐like growth factor binding protein‐4 (IGFBP‐4), thereby regulating local IGF availability. Reduced PAPP‐A mRNA expression has been reported in ovarian cancer specimens compared to normal ovarian surface epithelial cells