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Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2

✍ Scribed by Cui, Xiaojiang; Lazard, ZaWaunyka; Zhang, Ping; Hopp, Torsten A; Lee, Adrian V

Book ID: 110067890
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 207 KB
Volume: 22
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1206803

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## Abstract Insulin‐like growth factor‐I receptor (IGF‐IR) is often overexpressed in malignant tumors, and is involved in the establishment and maintenance of malignant phenotypes. Tyrosine kinase receptor endocytosis is commonly triggered by ligand binding and occurs via clathrin‐coated vescicles