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Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

✍ Scribed by Paley, M. A.; Kroy, D. C.; Odorizzi, P. M.; Johnnidis, J. B.; Dolfi, D. V.; Barnett, B. E.; Bikoff, E. K.; Robertson, E. J.; Lauer, G. M.; Reiner, S. L.; Wherry, E. J.

Book ID
118069970
Publisher
American Association for the Advancement of Science
Year
2012
Tongue
English
Weight
835 KB
Volume
338
Category
Article
ISSN
0036-8075

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πŸ“œ SIMILAR VOLUMES

Therapeutic vaccination against chronic
Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells
✍ Allan J Zajac; Kaja Murali-Krishna; Joseph N Blattman; Rafi Ahmed πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 English βš– 740 KB

The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral