## Abstract The prodynorphin gene (__PDYN__) encoding the anticonvulsant peptide dynorphin is a strong candidate for a seizure suppressor gene and thus a possible modulator of susceptibility to temporal lobe epilepsy. We performed a case control association study in 155 patients with nonlesional te
β¦ LIBER β¦
Prodynorphin gene promoter polymorphism and temporal lobe epilepsy
β Scribed by Nikola Tilgen; Johannes Rebstock; Steve Horvath; Peter Propping; Christian Erich Elger; Armin Heils
- Book ID
- 101464209
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 49 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0364-5134
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## Abstract Dynorphin neuropeptides are believed to act as endogenous anticonvulsants, though direct evidence for such a role in humans is sparse. We now report pronounced increases of prodynorphin mRNA expression in the dentate gyrus of patients with temporal lobe epilepsy in comparison to control
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