𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy

✍ Scribed by Elisabeth Stögmann; Alexander Zimprich; Christoph Baumgartner; Susanne Aull-Watschinger; Volker Höllt; Fritz Zimprich

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
203 KB
Volume
51
Category
Article
ISSN
0364-5134

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The prodynorphin gene (PDYN) encoding the anticonvulsant peptide dynorphin is a strong candidate for a seizure suppressor gene and thus a possible modulator of susceptibility to temporal lobe epilepsy. We performed a case control association study in 155 patients with nonlesional temporal lobe epilepsy and 202 controls and found that PDYN promotor low‐expression L‐alleles confer an increased risk for temporal lobe epilepsy in patients with a family history for seizures. Irrespective of the familial background, L‐homozygotes display a higher risk for secondarily generalized seizures and status epilepticus.

📜 SIMILAR VOLUMES

A polymorphism in the CYP17 gene is asso
A polymorphism in the CYP17 gene is associated with prostate cancer risk
✍ Andrea Gsur; Gabriele Bernhofer; Sonja Hinteregger; Gerald Haidinger; Georg Scha 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 63 KB 👁 2 views

CYP17 encodes the enzyme cytochrome P-450c17␣, which mediates both 17␣-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog

Lack of association between temporal lob
Lack of association between temporal lobe epilepsy and a novel polymorphism in the alpha 2 subunit gene (ATP1A2) of the sodium potassium transporting ATPase
✍ Buono, R.J.; Ferraro, T.N.; O'Connor, M.J.; Sperling, M.R.; Abbey, M.; Finanger, 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 12 KB 👁 1 views

Genetic linkage studies in rodents and humans have identified specific chromosomal regions harboring seizure susceptibility genes. We have identified a novel polymorphism in the human alpha 2 subunit gene (ATP1A2) of the sodium potassium transporting ATPase (NaK-pump), a candidate gene for human tem

A functional glutathione S-transferase P
A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population
✍ Tasuku Hashimoto; Kenji Hashimoto; Daisuke Matsuzawa; Eiji Shimizu; Yoshimoto Se 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 70 KB 👁 2 views

## Abstract Several lines of evidence suggest that oxidative stress plays a role in the mechanisms of action of methamphetamine (MAP) in the human brain. Given the role of glutathione __S__‐transferases (GSTs) in the protection against oxidative stress, genes encoding the GSTs have been considered