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Production of (+)-(S)-Ethyl 3-Hydroxybutyrate and (-)-(R)-Ethyl 3-Hydroxybutyrate by Microbial Reduction of Ethyl Acetoacetate

✍ Scribed by Beat Wipf; Ernst Kupfer; Roberto Bertazzi; Hans Georg Wilhelm Leuenberger

Book ID: 102252819
Publisher: John Wiley and Sons
Year: 1983
Tongue: German
Weight: 218 KB
Volume: 66
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19830660209

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✦ Synopsis

Abstract

The production of (S)‐ethyl 3‐hydroxybutyrate (2) from ethyl acetoacetate (1) in higher yields and with higher optical purity than with the usual procedures was achieved by continuous addition of the substrate 1 and sucrose to an aerated suspension of bakers' yeast. The microbial reduction of 1 by the fungus Geotrichum candidum LINK yields ‐ for the first time ‐ the antipode 3.

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