𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Preparation of Ethyl (R)-(−)-3-Hydroxy-2-methylpropanoate by Yeast Reduction of Ethyl α-Formylpropanoate

✍ Scribed by Max F. Züger; Fabio Giovannini; Prof. Dr. Dieter Seebach

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
138 KB
Volume
22
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Preparation by yeast reduction and deter
Preparation by yeast reduction and determination of the sense of chirality of enantiomerically pure ethyl (−)-4,4,4-trichloro-3-hydroxy- and (+)-4,4,4-trifluoro-3-hydroxybutanoate
✍ Dieter Seebach; Philippe Renaud; W. Bernd Schweizer; Max F. Züger; Marie-Josèphe 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 German ⚖ 709 KB

## Abstract Reduction of ethyl 4,4,4‐trichloro‐ and 4,4,4‐trifluoro‐3‐oxobutanoate by fermenting baker's yeast (__Saccharomyces cerevisiae__) on a preparative scale (20–50 g in __ca__. 3 1 of H~2~O) gave 70–80% yields of the trichloro‐ [(−)‐(__S__)‐**1a**] and trifluoro‐hydroxyesters [(+)‐(__R__)**