โ Scribed by Morgan, Gilbert T. ;Hardy, Douglas V. N.
No coin nor oath required. For personal study only.
Tlrc results of our studies of tlic modified iiictlinnol syntlicsis (Jlorpn, Ilnrdy, iind l'roctor, ,J.S.C.I., 1032, 51, 1 T) arc in Iirirniony witli tlic nldol theory, wliicli postulates thc forinntion of liiglter nlcoliols nntl iiltlcliydcs froiu lower nldchydcs by siicccssivc processes of rildolization, clcliydrrttion, rind hydrogcnntion :
A corollary of this theory is tlirit every iiltlcliydc iiirty either nldolizc or undcrgo hydrogcnntion, or rcnct, in both these ways. Consequently tlic inore complex alcohols might be cspcctcd to occur in sninllcr proportions. This is not tlic case for tlic first iiieiiibcrs of the homologous series of :~lcohols, but it holds frorn tlic C4-alcohols upwards. Morcorcr, considcrrition of tlic dtlol reactions rcrcnls tlic fact tliiit tlic conditions cniployed in thc modified mctlirinol synthesis ciin hnrdly be those 1JcSt suited to thc proiliiction of higher nlcoliols etc. siiicc tlicy riiin principnlly :it Iiydrogcnntion. It follows that the modified 111cthii110l synthesis is probnbly not the best method for producing liigli alcoliols, niid we linrc becn led to consider tlic IiosssilJilitics of a multistage process basccl on tlic reactions indicntcd by the aldol theory.
The nldol condcnsiition is ilpplic:~ble to nldeliydcs and ketones, and to inisturcs of iildcliydcs iind kctoncs, so that i t nmay bc gcncr:ilizcd as follows :
i t c i r , ~c ~i i t ~~c ~~, o i ~ wlicrc R, R', R" nnd It"' niny be hydrogen atoms, or
๐ SIMILAR VOLUMES
Using a magnesium-Oppenauer oxidation aldehydes and ketones are prepared from halomagnesium alkoxides, which in turn are the products of Grignard reactions.