Production of desferrioxamine E and new analogues by directed fermentation and feeding fermentation

✍ Scribed by Johannes Meiwes; Hans-Peter Fiedler; Hans Zähner; Silvia Konetschny-Rapp; Günther Jung

• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 563 KB
• Volume: 32
• Category: Article
• ISSN: 1432-0614
• DOI: 10.1007/bf00173718

✦ Synopsis

Streptomyces olivaceus TU 2718 produces the siderophore desferrioxamine E. Production depends on L-lysine and iron concentrations in the medium. With optimized conditions the yield of desferrioxamine E could be increased to 12 g/l in feeding fermentations. Supplementation of the basic production medium with natural and synthetic precursors of desferrioxamine E led to the production of twelve new analogues of desferrioxamine E.