Production of chemokines by tumorigenic keratinocyte cell lines harboring human papillomavirus (HPV) type 16
✍ Scribed by Magdalena Malejczyk; Tomasz Grzela; Sławomir Majewski; Thomas Schwarz; Stefania Jabłońska; Jacek Malejczyk
- Book ID
- 108408830
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 188 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0165-2478
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## Abstract Keratinocytes immortalized by human papillomaviruses (HPV) 16 and 18 are partially resistant to the inhibition of proliferation exerted by transforming growth factor‐β (TGF‐β). To determine if this finding reflects a generalized resistance to inhibitory cytokines, we studied the effect
We and others have previously reported that human papillomavirus (HPV)-16 E6 protein expression sensitizes certain cell types to apoptosis. To confirm that this sensitization occurred in HPV's natural host cells, and to explore the mechanism(s) of sensitization, we infected human keratinocytes (HKCs