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Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts

✍ Scribed by George R. Dodge; David Hawkins; Eric Boesler; Lynn Sakai; Sergio A. Jimenez

Book ID
114476069
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
127 KB
Volume
6
Category
Article
ISSN
1063-4584

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Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti