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Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells

✍ Scribed by Schwab, Ulrich; Stein, Harald; Gerdes, Johannes; Lemke, Hilmar; Kirchner, Hartmut; Schaadt, Michael; Diehl, Volker

Book ID
109727438
Publisher
Nature Publishing Group
Year
1982
Tongue
English
Weight
442 KB
Volume
299
Category
Article
ISSN
0028-0836

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We re-appraised the cell renewal pattern in Hodgkin's disease (HD), considering that most, though not all, Hodgkinf Reed- ## Sternberg (H-RS) cells exhibit abortive mitoses and that a substantial fraction of these exhibits DNA damage suggestive of imminent or actual cell death. Using combined immu