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Production and Characterization of Reg Knockout Mice: Reduced Proliferation of Pancreatic -Cells in Reg Knockout Mice

✍ Scribed by Unno, M.; Nata, K.; Noguchi, N.; Narushima, Y.; Akiyama, T.; Ikeda, T.; Nakagawa, K.; Takasawa, S.; Okamoto, H.

Book ID
127241459
Publisher
American Diabetes Association
Year
2002
Tongue
English
Weight
305 KB
Volume
51
Category
Article
ISSN
0012-1797

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## Abstract ## Objective To determine the importance of the enzymatic activity of ADAMTS‐4 in normal growth and development and to evaluate the role of ADAMTS‐4 in the progression of osteoarthritis (OA). ## Methods We generated catalytic domain–deleted ADAMTS‐4–transgenic mice and performed exte