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Knockout of α-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice

✍ Scribed by Glaser, Shannon S; Ueno, Yoshiyuki; DeMorrow, Sharon; Chiasson, Valorie L; Katki, Khurshed A; Venter, Julie; Francis, Heather L; Dickerson, Ian M; DiPette, Donald J; Supowit, Scott C


Book ID
109886176
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
567 KB
Volume
87
Category
Article
ISSN
0023-6837

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During bile duct ligation (BDL), the growth of large cholangiocytes is regulated by the cyclic adenosine monophosphate (cAMP)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway and is closely associated with increased secretin receptor (SR) expression. Although it has been suggested that SR