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Production and characterization of interferon from endothelial cells

✍ Scribed by Stefan Einhorn; Israel Vlodavsky; Zvi Fuks; Amiram Eldor; Amos Panet

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
555 KB
Volume
122
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

T h e capacity of cultured bovine aortic, capillary, and corneal endothelial cells as well as of human umbilical cord endothelial cells to produce interferon (IFN) was investigated. The endothelial cells of the two species produced significant amounts of IFN in response to various viruses and poly (I) poly (C). The IFN produced by human umbilical cord endothelial cells was a mixture of a-and 0-IFN, as determined by neutralization with antibodies directed against these two types of IFNs as well as by measuring the antiviral activity on heterologous cells. Bovine endothelial cells also produced a mixture of at least two IFN subspecies, one of them labile at pH 2 and active on human cells and the other stable at pH 2 and inactive on human cells.

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