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Production and auto-induction of transforming growth factor-α in human keratinocytes

✍ Scribed by Coffey, Robert J.; Derynck, Rik; Wilcox, Josiah N.; Bringman, Timothy S.; Goustin, A. Scott; Moses, Harold L.; Pittelkow, Mark R.


Book ID
109750292
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
566 KB
Volume
328
Category
Article
ISSN
0028-0836

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The effect of transforming growth factor-type f3 l(TGF-P) on the growth and differentiation of normal human skin keratinocytes cultured in serum-free medium was investigated. TCF-P markedly inhibited the growth of keratinocytes at the concentrations >2 ng/ml under low Ca2+ conditions (0.1 mM). Growt