✦ LIBER ✦

Modulation of growth and differentiation in normal human keratinocytes by transforming growth factor-β

✍ Scribed by Kunio Matsumoto; Koji Hashimoto; Makoto Hashiro; Hidenobu Yoshimasa; Kunihiko Yoshikawa

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 722 KB
Volume: 145
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041450114

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of transforming growth factor-type f3 l(TGF-P) on the growth and differentiation of normal human skin keratinocytes cultured in serum-free medium was investigated. TCF-P markedly inhibited the growth of keratinocytes at the concentrations >2 ng/ml under low Ca2+ conditions (0.1 mM). Growth inhibition was accompanied by changes in cell functions related to proliferation. Remarkable inhibition of DNA synthesis was demonstrated by the decrease of

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