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Proconvulsive effects of the mitochondrial respiratory chain inhibitor — 3-nitropropionic acid

✍ Scribed by Grzegorz Haberek; Tomasz Tomczyk; Beata Zuchora; Marian Wielosz; Waldemar A Turski; Ewa M Urbanska


Book ID
114013263
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
103 KB
Volume
403
Category
Article
ISSN
0014-2999

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## Abstract Cyclosporin A (CyA), a potent immunosuppressant, was used to determine the hepatotoxic effect in long‐term treatments. Male Wistar rats were used in these experiments. They were given CyA chronically at doses used in patients for 120 days, and at doses of 5, 10, 15 and 20 mg kg^−1^ day^