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In vitro effects of silver nanoparticles on the mitochondrial respiratory chain

✍ Scribed by Cláudio Sérgio Costa; João Vitor Vieira Ronconi; Juliana Felipe Daufenbach; Cinara Ludvig Gonçalves; Gislaine Tezza Rezin; Emilio Luiz Streck; Marcos Marques da Silva Paula

Publisher
Springer
Year
2010
Tongue
English
Weight
330 KB
Volume
342
Category
Article
ISSN
0300-8177

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## Abstract Cyclosporin A (CyA), a potent immunosuppressant, was used to determine the hepatotoxic effect in long‐term treatments. Male Wistar rats were used in these experiments. They were given CyA chronically at doses used in patients for 120 days, and at doses of 5, 10, 15 and 20 mg kg^−1^ day^