Galambos et al. (l) , in making their opening comments concerning the usefulness of an assay for Type I11 procollagen N-terminal peptide, state that normal liver contains 5.5 mg of collagen per gm of which 80% is Type I collagen and 15% is Type I11 collagen. They further state that the endstage cir
Procollagen III peptide (PIIIP): Can it reflect hepatic fibrosis?
โ Scribed by Joseph Alcorn; Mario Chojkier
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 405 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0270-9139
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Recent studies suggest that the serum level of Type I11 procollagen (PC-III) could be a valuable, noninvasive monitor of hepatic fibrogenesis. We have developed a sensitive and specific radioimmunoassay for PC-I11 procollagen isolated and purified from fetal goat skin which shows high cross-reaction
To assess the value of type I11 procollagen peptide (sPIIIP) as a marker of hepatic fibrosis, sera from 73 patients with alcohol-related liver disease and 30 patients with idiopathic hemochromatosis (IHC) were studied by a specific radioimmunoassay. sPIIIP was increased in 87% of 30 patients with ci