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Prochloraz as potent inhibitor of benzo[a]pyrene metabolism and mutagenic activity in rat liver fractions

✍ Scribed by Antignac, E.; Koch, B.; Grolier, P.; Cassand, P.; Narbonne, J.F.

Book ID
122339080
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
427 KB
Volume
54
Category
Article
ISSN
0378-4274

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## Abstract A rat liver microsome‐mediated bacterial mutagenicity test showed 9‐hydroxybenzo (__a__) pyrene to be significantly more effective as a pre‐mutagen than benzo (__a__) pyrene. Experiments measuring the ability of these compounds to be metabolically activated to moieties that alky late ex