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Prochiral sulfides as in vitro probes for multiple forms of the flavin-containing monooxygenase

โœ Scribed by Allan E. Rettie; G.P. Meier; A.J.M. Sadeque


Book ID
113137725
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
894 KB
Volume
96
Category
Article
ISSN
0009-2797

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Prochiral sulfide probes for the active-
โœ Michael B. Fisher; Allan E. Rettie ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 385 KB

Mammalian flavin-containing monooxygenases are known to oxygenate prochiral sulfides often with a high degree of stereoselectivity. In the present study we used two homologous series of n-alkyl aryl sulfides, Ar-S-(CH2)nH, (where Ar=p-tolyl or 2-naphthyl and n=l-7), to probe the active site topograp