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Processing mechanism of amyloid precursor protein (APP) to produce beta/A4 protein in Alzheimer's disease brain

✍ Scribed by Mori, Hiroshi

Book ID: 123041669
Publisher: Elsevier Science
Year: 1992
Weight: 97 KB
Volume: 17
Category: Article
ISSN: 0921-8696
DOI: 10.1016/0921-8696(92)90670-V

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## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve