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Procathepsin D activation peptide and its fragments in regulation of cancer growth

✍ Scribed by Vaclav Vetvicka; Jana Vetvickova; Zdenek Voburka; Martin Fusek

Book ID
117348567
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
124 KB
Volume
94
Category
Article
ISSN
0167-0115

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Cathepsin D, a lysosomal aspartic proteinase, is secreted in the form of enzymatically inactive proenzyme by many types of human breast cancer tissue and exerts mitogenic activity toward these tissues. Flow cytometry was used to test the binding of procathepsin D purified from the secretion of the b