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Regulation of GTPase and adenylate cyclase activity by amyloid β-peptide and its fragments in rat brain tissue

✍ Scribed by Ursel Soomets; Riina Mahlapuu; Roya Tehranian; Jüri Jarvet; Ello Karelson; Mihkel Zilmer; Kerstin Iverfeldt; Matjaz Zorko; Astrid Gräslund; Ülo Langel

Book ID
114005459
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
187 KB
Volume
850
Category
Article
ISSN
0006-8993

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## Abstract Although alterations in adenylate cyclase (AC) activity and somatostatin (SRIF) receptor density have been reported in Alzheimer's disease, the effects of amyloid β‐peptide (Aβ) on these parameters in the hippocampus are unknown. Our aim was to investigate whether the peptide fragment A