Three cases of hypersensitivity to oral procarbazine (Matulanea) are described. All occurred during 4-drug combination chemotherapy of Hodgkin's disease. T w o reactions primarily involved the skin. The third patient manifested recurrent fever, pulmonary infiltration, pleural effusion, and eosinophi
Procarbazine hypersensitivity manifested as a fixed drug eruption
โ Scribed by Giguere, Jeffrey K. ;Douglas, Danny M. ;Lupton, George P. ;Baker, James R. ;Weiss, Raymond B.
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 345 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0098-1532
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โฆ Synopsis
A case of a previously unrecognized form of hypersensitivity to procarbazine characterized by a nonpigmented fixed drug eruption is reported. Despite skin testing, association of the skin lesion to procarbazine could be determined only by drug rechallenge. Various aspects of procarbazine hypersensitivity reactions as well as the pathogenesis and importance of the fixed drug eruption are discussed.
๐ SIMILAR VOLUMES
Eighty years have elapsed since fixed drug eruption was described (Brocq, 1894) but the mechanism of production is still unknown. Both immunological and toxic mechanisms have been implicated to explain the abnormal response of the skin to the administered drug, but there is no supporting evidence in