✦ LIBER ✦

Hypersensitivity to procarbazine (Matulane®) manifested by fever and pleuropulmonary reaction

✍ Scribed by Stephen E. Jones; Melvin Moore; Norman Blank; Ronald A. Castellino

Publisher: John Wiley and Sons
Year: 1972
Tongue: English
Weight: 316 KB
Volume: 29
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(197202)29:2<498::aid-cncr2820290240>3.0.co;2-o

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✦ Synopsis

Three cases of hypersensitivity to oral procarbazine (Matulanea) are described. All occurred during 4-drug combination chemotherapy of Hodgkin's disease. T w o reactions primarily involved the skin. The third patient manifested recurrent fever, pulmonary infiltration, pleural effusion, and eosinophilia ultimately demonstrated to be secondary tn procarbazine o n contrnlled challenge. T h e pertinent literature i s reviewed.