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Procainamide-induced thrombocytopenia

โœ Scribed by Robert Rosenstein; Rodney E. Kosfeld; Leonard Leight; Dr. Yong K. Liu

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
188 KB
Volume
16
Category
Article
ISSN
0361-8609

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A 56-year-old man developed procainamide-induced agranulocytosis. Bone marrow aspiration showed the absence of myeloid elements beyond the promyelocyte stage. Procainamide at therapeutic concentrations in vitro depressed bone marrow granulocyte-macrophage colonies (CFUc) while CFUc growth was normal