Another case of procainamide induced pancytopenia
β Scribed by Kulwant S. Gill; Ormille A. Hayne; Ekram Zayed
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 100 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
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We studied a patient being treated with procainamide in whom we observed a high antinuclear antibody titer and prolonged activated partial thromboplastin (PTT), prothrombin (PT), and Stypven times (ST). Serum antibody concentrations against single-stranded DNA were elevated while those aginst native
We have reported that an inhibitor of DNA methylation, 5-azacytidine, makes cloned, antigenspecific CD4+ T cells autoreactive, and that procainamide and hydralazine mimic this effect. Those results suggested that procainamide and hydralazine may induce autoimmunity by inhibiting DNA methylation and