Problems of [S-methyl-11C]-L-methionine as a protein synthesis marker in the pancreas
β Scribed by Yasuhisa Fujibayashi; Keichi Kawai; Yoshiharu Yonekura; Kazuya Matsumoto; Junji Konishi; Akira Yokoyama
- Book ID
- 113001229
- Publisher
- Springer Japan
- Year
- 1990
- Tongue
- English
- Weight
- 413 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0914-7187
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The presence of D-enantiomer in L-[methyl-ttC]methionine prepared from [HC]CH3I and L-homocysteine thiolactone, was measured by high performance liquid chromatography using a reverse-phase column with an eluent containing L-proline and cupric acetate. The amount of D-enantiomer increased with concen
L-methionine is obtained in good yield and high e.e. by using the carboxylation of an enantiopurecr-lithiooxazolidinonepreparedby tin-lithiumexchange.The entire processfrom cs-stannyl oxazolidinonetakes 35-40mn,time which is compatiblewitb the use of 11C02in radioactive chemistry directedto PET imag