Clonal studies of adn.. chimaeric mouse epithelium have demonstrated the monoclonal composition of crypts of Lieberkuhd'). In neonatal life, however, polyclonal crypts have been found, indicating that crypts are of polyclonal origid2). We here relate these findings to studies of mosaic tissues which
Problems and paradigms: Parochial, visionary and factual thinking on the origins of life
β Scribed by N. W. Pirie
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 276 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0265-9247
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Fundamental to a deeper understanding of complex biological functions are ideas about how life originated and evolved. They include questions about how the first compounds, essential to life, appeared on Earth; how the first replicating molecules came into being; how RNA and DNA were formed; how pro
Models for the steps of organisation in the origin of life are discussed with an emphasis on stability, and the possibilities of acquiring a diversity of functions. In particular, two basic models are described: that of simple self-replicating molecules, and that of autocatalytic self-reproduction,