Problems and paradigms: On the clonal origin of tumours – lessons from studies of intestinal epithelium
✍ Scribed by Günter H. Schmidt; Roger Mead
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 495 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0265-9247
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✦ Synopsis
Clonal studies of adn.. chimaeric mouse epithelium have demonstrated the monoclonal composition of crypts of Lieberkuhd'). In neonatal life, however, polyclonal crypts have been found, indicating that crypts are of polyclonal origid2). We here relate these findings to studies of mosaic tissues which have addressed the question whether solid tumours are of monoclonal or polyclonal origin (ref. 3 for review, 4). The issues has so far remained unresolved because the expected frequencies of polyclonal tumours, given polyclonal origins, have not previously been estimated. A general approach for the calculation of such expected values is suggested. The consistent reports of tumours with polyclonal components suggest that autocrine or paracrine mechanisms play an important role during tumorigenesis.