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Probing the structure and function of viral RNA genomes

✍ Scribed by Donald L. Nuss; Amiya K. Banerjee

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 800 KB
Volume: 7
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950070604

No coin nor oath required. For personal study only.

✦ Synopsis

The majority of human, animal andplant viral pathogens possess genomes composed of RNA. The strategies evolved for expression and replication of viral RNA genomes can differ signijicantly from those utilized for expression and replication of host-cell genetic material. Consequently, knowledge of the molecular details of these strategies can lead to a clearer understanding of the origin, evolu-tion and control of viral pathogens. We describe recent progress in identifVing important structural and functional domains of the RNA genomes and associated replicative enzymes for two very diferent viruses

: vesicular stomatitis virus, which possesses a single-stranded RNA genome of negative polarity, and wound tumor virus, which contains a genome composed of 12 discrete segments of double-stranded RNA.

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