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Probing the inhibitor-binding site of aldose reductase with site-directed mutagenesis

โœ Scribed by Thomas C. Hohman; Ossama El-Kabbani; Michael S. Malamas; Kehdih Lai; Tatiana Putilina; Michelle H. McGowan; Yi-Qun Wane; Deborah A. Carper


Book ID
114429338
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
636 KB
Volume
256
Category
Article
ISSN
1432-1327

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Structure of rat aldose reductase-like p
โœ Krithika Sundaram; Urmi Dhagat; Satoshi Endo; Roland Chung; Toshiyuki Matsunaga; ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 353 KB

Rat aldose reductase-like protein (AKR1B14) is the ortholog of mouse vas deferens protein (AKR1B7) playing roles in detoxification of reactive aldehydes and synthesis of prostaglandin F 2a . The crystal structure of the binary complex (AKR1B14-NADPH) was determined at 1.86 ร… resolution, and showed t