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Site-directed mutagenesis of His-42, His-188 and Lys-263 of human aldose reductase

โœ Scribed by Takashi Yamaoka; Yoshiharu Matsuura; Kamejiro Yamashita; Tsuyoshi Tanimoto; Chihiro Nishimura


Book ID
115765466
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
503 KB
Volume
183
Category
Article
ISSN
0006-291X

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Structure of rat aldose reductase-like p
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Rat aldose reductase-like protein (AKR1B14) is the ortholog of mouse vas deferens protein (AKR1B7) playing roles in detoxification of reactive aldehydes and synthesis of prostaglandin F 2a . The crystal structure of the binary complex (AKR1B14-NADPH) was determined at 1.86 ร… resolution, and showed t