Probing the Immune Dysregulation in Cutaneous T Cell Lymphomas
β Scribed by Heald, Peter
- Book ID
- 110735679
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 33 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0022-202X
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The genes encoding the T-cell receptor (TCR) variable beta (TCRBV) regions were studied in skin biopsy samples from 24 patients with cutaneous T-cell lymphomas (CTCL), i.e. mycosis fungoides (n = 7), SΓ©zary syndrome (n = 4), lymphomatoid papulosis (n = 3) and large cell CTCL with (n = 3) or without
## Abstract ## BACKGROUND. Lungs are among the most common organs of extranodal involvement by cutaneous Tβcell lymphomas (CTCLs), yet the magnitude of lung involvement is not clear, and only a few case reports have addressed this issue to date. The objective of this study was to present the autho
Genomic DNA digests of skin biopsies from 20 patients with cutaneous T-cell lymphomas and pseudolymphomas were studied by hybridization, using probes for the constant region of the T-cell receptor beta chain and the joining region of the immunoglobin heavy chain gene. Skin biopsies from all 20 patie