✦ LIBER ✦

Dual genotype in cutaneous T-cell lymphomas and pseudolymphomas

✍ Scribed by Y. J. Bignon; P. Souteyrand; H. Roger; D. Bernard; B. Dastugue; F. Ramos; M. d'Incan; P. Chollet; R. Plagne

Publisher: Springer
Year: 1990
Tongue: English
Weight: 397 KB
Volume: 84
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00208936

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✦ Synopsis

Genomic DNA digests of skin biopsies from 20 patients with cutaneous T-cell lymphomas and pseudolymphomas were studied by hybridization, using probes for the constant region of the T-cell receptor beta chain and the joining region of the immunoglobin heavy chain gene. Skin biopsies from all 20 patients contained a monoclonal T-cell population. In addition, DNA from 5 patients contained an immunoglobulin gene rearrangement. These results demonstrate that cutaneous T-cell lymphomas are clonal T-cell malignancies that frequently express a dual genotype, which may sometimes reflect the clonotypic heterogeneity of these disorders.

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