𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Expression of cancer/testis antigens in cutaneous T cell lymphomas

✍ Scribed by Andreas C. Häffner; Anatoli Tassis; Karoline Zepter; Monique Storz; Oezlem Tureci; Günter Burg; Frank Oliver Nestle

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
624 KB
Volume
97
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cancer/testis‐antigens (CTA), a novel and expanding family of immunogenic proteins detected by serological screening of recombinant cDNA expression libraries, encompass promising candidate targets for T‐cell based immunotherapy. We screened kryo‐preserved tissue of cutaneous T cell lymphoma (CTCL, n=36) such as mycosis fungoides (MF, n=17), pleomorphic cutaneous T‐cell lymphoma (n=8) and Sezary's syndrome (SS, n= 11) as well as a non‐malignant entity (small plaques parapsoriasis, SPP, n=5), for the expression of CTA by RT‐PCR and Northern blot hybridization. From a panel of eleven CTA (MAGE‐1, MAGE‐C1, MAGE‐3, BAGE, GAGE, SSX‐1, SSX‐2, SSX4, SCP‐1, NY‐ESO‐1 and TS85) (HOM‐Tes‐85), mRNA expression could be detected for SCP‐1 in 8/17 MF and 6/8 pleomorphic CTCL patients but was completely absent in small plaques parapsoriasis. SS patients had a more heterogeneous antigen expression pattern: Gage (1/11), MAGE‐1 (3/11), MAGE‐3 (6/11), MAGE‐C1 (5/11), NY‐ESO‐1 (7/11) and TS85 (5/11), with expression of MAGE‐3 confirmed by immunohistochemistry. CTA could provide defined targets for antigen‐based vaccination in a high percentage of cases with CTCL. SCP‐1 might serve as an additional diagnostic indicator in early and clinically indistinct lesions suspicious for cutaneous T‐cell lymphoma. © 2001 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Tumor-specific antigens in cutaneous T-c
Tumor-specific antigens in cutaneous T-cell lymphoma: Expression and sero-reactivity
✍ Stefan Eichmüller; Dirk Usener; Daniela Thiel; Dirk Schadendorf 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 142 KB 👁 1 views

## Abstract Cutaneous T‐cell lymphoma (CTCL) is a heterogeneous group of extra‐nodal non‐Hodgkin lymphomas with primary manifestation in the skin with poor treatment options in the advanced stages. As basis for future immune‐therapeutic strategies we have investigated the possible expression of tum

CCR10 is expressed in cutaneous T-cell l
CCR10 is expressed in cutaneous T-cell lymphoma
✍ Mike Notohamiprodjo; Stephan Segerer; Ralf Huss; Bernhard Hildebrandt; Dulce Sol 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French

## Abstract Cutaneous T‐cell lymphoma (CTCL) is characterized by recruitment of malignant T‐cell clones into the skin. The mechanisms involved in tumor homing are still not fully elucidated, though chemokines and chemokine receptors have been suggested to play a role in the pathogenesis. Here, we d

Expression of cancer testis antigens in
Expression of cancer testis antigens in head and neck squamous cell carcinomas
✍ David L. A. Figueiredo; Rui C. M. Mamede; Rodrigo Proto-Siqueira; Luciano Neder; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 2 views

## Abstract ## Background. There is considerable interest in the expression of cancer testis (CT) antigens in human cancers, because they may serve as the basis for diagnostic tests or an immunologic approach to therapy, or as prognostic markers. ## Methods. On this basis, we evaluated by semiqu

Methylation-regulated expression of canc
Methylation-regulated expression of cancer testis antigens in primary effusion lymphoma: Immunotherapeutic implications
✍ Luana Calabrò; Ester Fonsatti; Maresa Altomonte; Laura Pezzani; Francesca Colizz 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 94 KB 👁 2 views

## Abstract Primary effusion lymphoma (PEL) is a large B‐cell neoplasm with an unfavorable prognosis and limited therapeutic options. In this study, cancer testis antigens (CTA) were investigated as potential immunotherapeutic targets in patients with PEL. Baseline expression of a panel of 11 CTA w

Cancer/testis antigen expression and spe
Cancer/testis antigen expression and specific cytotoxic T lymphocyte responses in non small cell lung cancer
✍ Célia Groeper; Franco Gambazzi; Paul Zajac; Lukas Bubendorf; Michel Adamina; Rac 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 501 KB

## Abstract Non small cell lung cancers (NSCLC) express cancer/testis antigens (CTA) genes and MAGE‐A expression correlates with poor prognosis in squamous cell carcinomas. We addressed cytotoxic T lymphocytes (CTL) responses to HLA class I restricted CTA epitopes in TIL from NSCLC in an unselected