✦ LIBER ✦

Probing Prometheus: Fat fueling the fire?

✍ Scribed by Geoffrey C. Farrell

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 70 KB
Volume: 40
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.20522

No coin nor oath required. For personal study only.

✦ Synopsis

In this issue of HEPATOLOGY, Shteyer, Rudnick, and colleagues provide new insights into metabolic factors and liver regeneration. 18 In a key experiment, they administered high dose (pharmacological) leptin to mice and successfully suppressed hepatic fat synthesis mediated by the process termed adipogenesis (because the genes involved are activated in the transition of preadipocytes to mature, fat-storing adipocytes). 19,20 Despite the apparently essen-

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