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Probes for narcotic receptor mediated phenomena 8. Tritiation of irreversible mu or delta specific opioid receptor affinity ligands to high specific activity

✍ Scribed by Terrence R. Burke Jr.; Kenner C. Rice; Arthur E. Jacobson; William F. Simonds; Werner A. Klee

Book ID: 102371592
Publisher: John Wiley and Sons
Year: 1984
Tongue: French
Weight: 381 KB
Volume: 21
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580210802

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✦ Synopsis

Tritiation of the delta-specific opioid alkylating ligand FIT, 3 and the mu-specific opioid alkylating ligand BIT, 2 to high specific activity is described. Both compounds were derived from dibrominated amino intermediates (4 and lo, respectively) which were tritiated with tritium gas over Pd/C before conversion of the amine functions to isothiocyanates.

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