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Probenecid in CSF and plasma of rabbits and dogs measured by radioimmunoassay

✍ Scribed by W. L. Shei; J. Y. Mu; R. F. Cunningham; Z. H. Israili; P. G. Dayton

Publisher
Springer
Year
1977
Tongue
English
Weight
336 KB
Volume
53
Category
Article
ISSN
0033-3158

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✦ Synopsis

Probenecid (P) in CSF of rabbits and dogs was investigated using a new radioimmunoassay technique. In rabbits, under steady-state conditions, CSF/free plasma concentration ratios of P were found to be similar to those reported in man. The ratios were concentration dependent and less than 0.5 suggesting an inhibition of transport of the drug in CNS. Under nonsteady-state conditions, no clear evidence of a transport system was found in dogs.

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