✦ LIBER ✦

PRO-PROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE9 (PCSK9) VARIANT DATABASE: PRELIMINARY ANALYSIS

✍ Scribed by S.E. Leigh; T. Jakubcova; R.A. Whittall; S.E. Humphries

Book ID: 118422784
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 54 KB
Volume: 207
Category: Article
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2009.09.054

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Proprotein convertase subtilisin/kexin t

Proprotein convertase subtilisin/kexin type 9 (PCSK9): From structure–function relation to therapeutic inhibition

✍ G. Tibolla; G.D. Norata; R. Artali; F. Meneghetti; A.L. Catapano 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 465 KB

Cellular and secreted pro-protein conver

Cellular and secreted pro-protein convertase subtilisin/kexin type 9 catalytic activity in hepatocytes

✍ Sanae Kourimate; Maud Chétiveaux; Anne Laure Jarnoux; Florent Lalanne; Philippe 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 648 KB

Proprotein convertase subtilisin/kexin t

Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects gene expression pathways beyond cholesterol metabolism in liver cells

✍ Hong Lan; Ling Pang; Marsha M. Smith; Diane Levitan; Wei Ding; Li Liu; Lixin Sha 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB

## Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9) induces degradation of low‐density lipoprotein receptor (LDLR) in the liver. It is being pursued as a therapeutic target for LDL‐cholesterol reduction. Earlier genome‐wide gene expression studies showed that PCSK9 over‐expression in

Proprotein convertase subtilisin kexin t

Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels

✍ Nicola Ferri; Gianpaolo Tibolla; Angela Pirillo; Francesco Cipollone; Andrea Mez 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 814 KB

Effect of protein convertase subtilisin/

Effect of protein convertase subtilisin/kexin type 9 (PCSK9) 46L gene polymorphism on LDL cholesterol concentration in a Polish adult population

✍ Grażyna Kostrzewa; Grażyna Broda; Paweł Kurjata; Walerian Piotrowski; Rafal Plos 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 108 KB

New hypotheses about the structure–funct

New hypotheses about the structure–function of proprotein convertase subtilisin/kexin type 9: Analysis of the epidermal growth factor-like repeat A docking site using WaterMap

✍ Robert A. Pearlstein; Qi-Ying Hu; Jing Zhou; David Yowe; Julian Levell; Bethany 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 681 KB

## Abstract LDL cholesterol (LDL‐C) is cleared from plasma via cellular uptake and internalization processes that are largely mediated by the low‐density lipoprotein cholesterol receptor (LDL‐R). LDL‐R is targeted for lysosomal degradation by association with proprotein convertase subtilisin‐kexin