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Proprotein convertase subtilisin/kexin type 9 (PCSK9): From structure–function relation to therapeutic inhibition

✍ Scribed by G. Tibolla; G.D. Norata; R. Artali; F. Meneghetti; A.L. Catapano

Book ID
116800663
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
465 KB
Volume
21
Category
Article
ISSN
0939-4753

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## Abstract LDL cholesterol (LDL‐C) is cleared from plasma via cellular uptake and internalization processes that are largely mediated by the low‐density lipoprotein cholesterol receptor (LDL‐R). LDL‐R is targeted for lysosomal degradation by association with proprotein convertase subtilisin‐kexin