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Prion protein abrogates bax-mediated cell death in human primary neuron cultures

✍ Scribed by Younes Bounhar; Yan Zhang; Maria Papadopoulos; Cynthia Goodyer; Jennifer Hammond; Andrea C. LeBlanc


Book ID
117412046
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
196 KB
Volume
21
Category
Article
ISSN
0197-4580

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We examined cytokine-mediated neuronal death in neuron-astrocyte cultures from second trimester human fetal cerebrum. In these cultures, high-output inducible nitric oxide synthase (NOS) and tumor necrosis factor-␣ (TNF␣) are expressed in astrocytes after exposure to IL-1␀/IFNβ₯. Neuronal cell death